The Basque Resource for Electron Microscopy (BREM) at the Instituto Biofisika offers resources, training and expertise in three-dimensional structure determination of vitrified biological specimens – macromolecules and their complexes, organelles, cells and tissues – with the goal of understanding biological processes and human disease pathogenesis, coupled with helping the development of therapeutic strategies.


Our data collection services are available to national and international researches, from academia and industry, and include high-resolution macromolecular electron cryo-microscopy (cryo-EM) and in situ electron cryo-tomography (cryo-ET). These services are enabled by equipment that is unique in Spain including a Krios G4 transmission electron cryo-microscope (cryo-TEM) and an Aquilos 2+ focused ion beam scanning electron cryo-microscope (cryo-FIB-SEM).


BREM has highly-skilled personnel to operate the facility and assist users with all major cryo-EM techniques available for structural biology.

Institutional Support