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2025

Structural basis for amyloid fibril assembly by the master cell-signaling regulator receptor-interacting protein kinase 1

Polonio P, López-Alonso JP, Jiang H, Andrés-Campos S, Escobedo-González FC, Titaux-Delgado GA, Ubarretxena-Belandia I & Mompeán M

Nat Commun (2025) 16, 9607

https://doi.org/10.1038/s41467-025-64621-6

A binding site for the antibiotic GE81112 in the ribosomal mRNA channel

Schedlbauer A, van Bakel W, Kaminishi T, Ochoa-Lizarralde B, Iturrioz I, Çapuni R, Parry R, Zegarra R, Gil-Carton D, López-Alonso JP, Barragan Sanz K, Brandi L, Gualerzi CO, Fucini P & Connell SR

mBio (2025) 0:e03978-24

https://doi.org/10.1128/mbio.03978-24

GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins

Vega-Gutiérrez C, Picañol-Párraga J, Sánchez-Valls I, Ribón-Fuster VP, Soto D & Herguedas B

Nat Struct Mol Biol (2025)

https://doi.org/10.1038/s41594-025-01666-7

A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection

Jabalera Y, Tascón I, Samperio S, López-Alonso JP, Gonzalez-Lopez M, Aransay AM, Abascal-Palacios G, Beisel CL, Ubarretxena-Belandia I & Perez-Jimenez R

Nat Biotechnol (2025) 43, 1663-1672

https://doi.org/10.1038/s41587-024-02461-3

The minimal chemotactic cell

Borges-Fernandes B, Apriceno A, Arango-Restrepo A, Almadhi S, Ghosh S, Forth J, López-Alonso JP, Ubarretxena-Belandia I, Rubi JM, Ruiz-Pérez L, Williams I & Battaglia G

Science Adv (2025) 11, eadx9364

https://doi.org/10.1126/sciadv.adx9364

Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions

Santos-Aledo A, Plaza-Pegueroles A, Sanz-Murillo M, Ruiz FM, Hou P, Xu J, Gil-Carton D, Wang D & Fernández Tornero C

Nat Commun (2025) 16, 5254

https://doi.org/10.1038/s41467-025-60536-4

2024

Structural basis for regulated expression of a CBASS- CRISPR-Cas defense island by a membrane anti-σ factor and its ECF σ partner 

Bernal-Bernal D, Pantoja-Uceda D, López-Alonso JP, Tascón I, López-Rojo A, Ochoa-Lizarralde B, López-Ruiz JA, Galbis-Martínez M, Elías-Arnanz M, Ubarretxena-Belandia I & Padmanabhan S

Science Adv (2024) 10, eadp 1053

https://doi.org/10.1126/sciadv.adp1053

Molecular basis for transposase activation by a dedicated AAA+ ATPase

Gándara A, Spínola-Amilibia M, Araújo-Bazán L, Núñez-Ramírez R, Berger JM & Arias-Palomo E

Nature (2024) 630, 1003-1011

https://doi.org/10.1038/s41586-024-07550-6

Membrane fission via transmembrane contact

Spencer RKW, Santos-Pérez I, Rodríguez-Renovales I, Martinez Galvez JM, Shnyrova AV & Müller M

Nat Commun (2024) 15, 2793

https://doi.org/10.1038/s41467-024-47122-w

Mechanism of allosteric inhibition of RUVBL1-RUVBL2 ATPase by the small molecule CB-6644

García-Martín C, López-Perrote A, Boskovic J & Llorca O

Cell Rep Phys Sci (2024) 5, 101982

https://doi.org/10.1016/j.xcrp.2024.101982

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation

Brito C, Serna M, Guerra P, Llorca O & Surrey T

Science (2024) 383, 870-876

https://doi.org/10.1126/science.adk6160

2023

Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane.

Magaña A, Tascón I, Altuna-Alvarez J, Queralt-Martin M, Colautti J, Velázquez C, Zabala M, Rojas-Palomino J, Cárdenas M, Alcaraz A, Whitney JC, Ubarretxena-Belandia I & Albesa-Jové D

Nat Commun (2023) 14, 7808

https://doi.org/10.1038/s41467-023-43585-5